Neurite outgrowth and synaptogenesis

Dr. Lagenaur's research interests center on cell recognition events that are important in synapse formation and function. The laboratory is currently studying two cell adhesion molecules, SIRP and CD47 which bind to one another and are localized to sites of synaptic contact. Both molecules have signaling capabilities and may be involved in regulation of synaptic plasticity. The goal of the laboratory's research is to determine how SIRP and CD47 signaling modify synaptic function. Work in collaboration with Drs. Cui and Weber, Dept. of Bioengineering, explore the use of neural cell adhesion molecules to improve bio-compatibility of chronic neural implants. Trainees in Dr. Lagenaur's laboratory have the opportunity to learn a variety of molecular and cell biological techniques such as cell culture, video microscopy, in situ hybridization, and immunochemical techniques for investigating biochemistry of signal transduction molecules in the central nervous system.

Sample Publications:

The surface immobilization of the neural adhesion molecule L1 on neural probes and its effect on neuronal density and gliosis at the probe/tissue interface.
Azemi E, Lagenaur CF, Cui XT.
Biomaterials. 2011 Jan;32(3):681-92.

Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes: In vitro characterization.
Azemi E, Stauffer WR, Gostock MS, Lagenaur CF, Cui XT.
Acta Biomater. 2008 Sep;4(5):1208-17.

Self-assembled monolayers of polythiophene conductive polymers improve biocompatibility and electrical impedance of neural electrodes.
Widge AS, Jeffries-El M, Cui X, Lagenaur CF, Matsuoka Y.
Biosens Bioelectron. 2007 Mar 15;22(8):1723-32.

Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons.
He K, Huang J, Lagenaur CF, Aizenman E.
J Pharmacol Exp Ther. 2006 Jun;317(3):1320-9.

Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode.
Wadhwa R, Lagenaur CF, Cui XT.
J Control Release. 2006 Feb 21;110(3):531-41.

An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.
Lagenaur C, Lemmon V.
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7753-7.

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