Assistant Professor, Neurobiology
Ph.D., Duke University (2001)
Address: W1458 BSTWR
200 Lothrop Street
Pittsburgh, PA 15213-2536
Cortical circuitry in health and disease
Research in Dr. Fanselow’s laboratory focuses on several topics:Epilepsy treatment via trigeminal nerve stimulation (TNS)
The trigeminal nerve is a cranial nerve that transmits information from the face to the brain. For reasons that are not yet clear, electrical stimulation of this nerve can reduce seizure activity in animals and in human epilepsy patients. Dr. Fanselow’s current work in this area is designed to understand the mechanism(s) by which TNS alters neuronal activity and alleviates seizures. In addition, we are interested in optimizing the stimulus parameters for TNS, thus improving the technique for application in humans.Neuronal mechanisms of seizure generation
The process of seizure generation is known as ictogenesis. Much is known about what can make brain tissue seizure prone, but little is understood about what, acutely, generates a seizure. We study the roles of inhibitory and excitatory neurons in ictogenesis, using both in vivo and in vitro preparations.Role of inhibitory neurons in non-pathological brain function
We are also studying how inhibitory neurons influence cortical activity under non-pathological conditions. We focus on understanding the physiological roles of inhibitory neurons in the somatosensory-motor regions of the neocortex.
Techniques used in Dr. Fanselow’s laboratory:
Indwelling microwire electrode recordings:
In vitro patch-clamp techniques:
Postnatal maturation of somatostatin-expressing inhibitory cells in the somatosensory cortex of GIN mice.
LTS and FS inhibitory interneurons, short-term synaptic plasticity, and cortical circuit dynamics.
Trigeminal nerve stimulation: seminal animal and human studies for epilepsy and depression.
The roles of somatostatin-expressing (GIN) and fast-spiking inhibitory interneurons in UP-DOWN states of mouse neocortex.
Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex.
Neocortical Anatomy and Physiology, Chapter 29 in Epilepsy: A Comprehensive Textbook, 2nd Ed., Engel J and Pedley TA (eds).
Thalamic bursting in rats during different awake behavioral states.
Reduction of pentylenetetrazole-induced seizure activity in awake rats by seizure-triggered trigeminal nerve stimulation.
Behavioral modulation of tactile responses in the rat thalamocortical loop.
Hebb's dream: the resurgence of cell assemblies.
© Copyright 2001 - University
of Pittsburgh Department of Neurobiology