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Associate Professor, Neurobiology
Ph.D., University of Washington (1978)
Address: W1448 Starzl BST
Telephone: 412-648-9073
Fax: 412-648-1441
E-mail: lagenaur@pitt.edu
Neurite outgrowth and synaptogenesis
Dr. Lagenaur's research
interests center on cell recognition events that are important in synapse
formation and function. The laboratory is currently studying two cell
adhesion molecules, SIRP and CD47 which bind to one another and are localized
to sites of synaptic contact. Both molecules have signaling capabilities
and may be involved in regulation of synaptic plasticity. The goal of
the laboratory's research is to determine how SIRP and CD47 signaling
modify synaptic function.
Trainees in Dr. Lagenaur's laboratory have the opportunity to learn a
variety of molecular and cell biological techniques such as cell culture,
video microscopy, in situ hybridization, and immunochemical techniques
for investigating biochemistry of signal transduction molecules in the
central nervous system.
Sample Publications:
Lagenaur C, Lemmon V. An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7753-7.
Wadhwa R, Lagenaur CF, Cui XT. Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode. J Control Release. 2006 Feb 21;110(3):531-41. Epub 2005 Dec 19.
He K, Huang J, Lagenaur CF, Aizenman E. Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons. J Pharmacol Exp Ther. 2006 Jun;317(3):1320-9. Epub 2006 Mar 17.
Azemi E, Stauffer WR, Gostock MS, Lagenaur CF, Cui XT. Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes: In vitro characterization. Acta Biomater. 2008 Sep;4(5):1208-17. Epub 2008 Mar 20.
Widge AS, Jeffries-El M, Cui X, Lagenaur CF, Matsuoka Y. Self-assembled monolayers of polythiophene conductive polymers improve biocompatibility and electrical impedance of neural electrodes. Biosens Bioelectron. 2007 Mar 15;22(8):1723-32. Epub 2006 Oct 2.
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