Lillien, Laura E.|
Associate Professor, Neurobiology
Ph.D., University of Wisconsin, Madison (1985)
Address: W1454 BST
203 Lothrop Street
Pittsburgh, PA 15213-2548
CNS stem cells
The research in Dr. Lillien's laboratory addresses the mechanisms that regulate proliferation, cell fate determination, and migration in the developing cerebral cortex and retina. Environmental signals and intrinsic differences among progenitor cells contribute to the regulation of these processes, and their relative contributions are studied by using retrovirus mediated gene transfer. We are particularly interested in defining the molecular basis of intrinsic differences among neural stem cells. This information will facilitate the design of stem cells that are optimal for specific clinical applications.
Students in Dr. Lillien's laboratory will have the opportunity to construct recombinant retroviruses expressing wild type and mutant genes, infect progenitor cells in the cortex or retina of rats and mice in vitro and in vivo with these viruses, generate genetically engineered CNS stem cells and transplant them into embryonic and postnatal forebrain.
Akt1 interacts with epidermal growth factor receptors and hedgehog signaling to increase stem/transit amplifying cells in the embryonic mouse cortex.
Environmental signals elicit multiple responses in dorsal telencephalic progenitors by threshold-dependent mechanisms.
Attraction or repulsion: a matter of individual taste?
Akt-1 expression level regulates CNS precursors.
Sonic hedgehog and bone morphogenetic protein regulate interneuron development from dorsal telencephalic progenitors in vitro.
Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2.
Epidermal growth factor receptors control competence to interpret leukemia inhibitory factor as an astrocyte inducer in developing cortex.
© Copyright 2001 - University
of Pittsburgh Department of Neurobiology