Seal, Rebecca P., Ph.D.|
Assistant Professor, Neurobiology
Address: 6058 BST3
3501 Fifth Avenue
Pittsburgh, PA 15213-3301
The Seal laboratory is interested in elucidating the circuitry that drives behavior normally and in disease. We currently have two major areas of focus: 1) the somatosensory system, which detects touch, temperature and pain and 2) forebrain circuits that influence motor behavior and drug addiction. We aim to discover fundamental principals and mechanisms of the nervous system as well as identify novel treatment strategies for nervous system disorders.
Experimental Approach: our laboratory uses mice as a model system and techniques such as virally-mediated DREADDs activation or inhibition of neurons, virally-mediated anterograde and retrograde circuit tracing, slice electrophysiology with optogenetics, confocal and 2-photon microscopy, molecular biology, histology, biochemistry and behavior.
See complete publication list on PubMed or Google Scholar
Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease.
Targeting Toll-like receptors to treat chronic pain.
Dorsal Horn Circuits for Persistent Mechanical Pain.
Striatal Cholinergic Neurotransmission Requires VGLUT3.
Striatal cholinergic interneurons drive GABA release from dopamine terminals.
Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.
Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors.
Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.
© Copyright 2001 - University
of Pittsburgh Department of Neurobiology