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![]() | Yip,
Joseph W. Associate Professor, Neurobiology Ph.D., University of California, San Francisco (1977) Address: E1455 BST Telephone: 412-648-9414 Fax: 412-648-1441 E-mail: jyip+@pitt.edu Neuronal migration and axonal
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Dr. Yips group
is interested in neuronal proliferation, migration and axon guidance.
Their current research on the chick and mouse sympathetic system is aimed
at determining: 1) whether the specification of preganglionic neurons
is under genetic or epigenetic control, 2) the pathway and guidance cues
in the migration of preganglionic neurons, and 3) whether the projection
of preganglionic axons toward their target area is guided by chemoattractant
molecules. Neural transplantations, tissue culture, BrdU labeling, lineage
tracers, monoclonal antibody production, immunohistochemistry, in situ
hybridization, anterograde and retrograde neuronal tracings, and light
and electromicro- scopy are used in the pursuit of these problems. Trainees in Dr. Yips laboratory have the opportunity to learn how to combine modern cell and molecular biological techniques and classical techniques in experimental embryology to answer major unresolved questions on neural development. Yip, J.W. Specificity of sympathetic preganglionic projections in the chick is influenced by the somitic mesoderm. J. Neurosci. 16: 612-620, 1996. Yip, J.W., Yip, Y.P.L., and Capriotti, C. Specific projections of sympathetic preganglionic neurons are not intrinsically determined by segmental origins of their cell bodies. J. Neurobiol., 35: 371-378, 1998. Yip, J.W., Yip, Y.P.L, and Capriotti, C. Segmented specificity of chick sympathetic preganglionic projections is influenced by preganglionic neurons from neighboring spinal cord segments. J. Neurosci 18: 10473-10480, 1998. Yip, J.W., Yip, Y.P.L., Nakajima, K., and Capriotti, C. Reelin controls position of autonomic neurons in the spinal cord. Proc. Natl. Acad. Sci. U.S.A., 97: 8612-8616 (2000).
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Copyright 2001 - University
of Pittsburgh Department of Neurobiology | |||||||||||||