Joe Yip

Yip, Joseph W.
Associate Professor, Neurobiology
Ph.D., University of California,
San Francisco (1977)
Address: E1455 BSTWR
200 Lothrop Street
Pittsburgh, PA 15213-2536
Telephone: 412-648-9414
Fax: 412-648-1441
E-mail:jyip@pitt.edu

Neuronal migration and axonal guidance

Dr. Yip's group is interested in neuronal proliferation, migration and axon guidance. Their current research on the chick and mouse sympathetic system is aimed at determining: 1) whether the specification of preganglionic neurons is under genetic or epigenetic control, 2) the pathway and guidance cues in the migration of preganglionic neurons, and 3) whether the projection of preganglionic axons toward their target area is guided by chemoattractant molecules. Neural transplantations, tissue culture, BrdU labeling, lineage tracers, monoclonal antibody production, immunohistochemistry, in situ hybridization, anterograde and retrograde neuronal tracings, and light and electromicro- scopy are used in the pursuit of these problems.

Trainees in Dr. Yip's laboratory have the opportunity to learn how to combine modern cell and molecular biological techniques and classical techniques in experimental embryology to answer major unresolved questions on neural development.

Sample Publications:

Migration of sympathetic preganglionic neurons in the spinal cord of a C3G deficient mouse suggests that C3G acts in the reelin signaling pathway.
Yip YP, Thomas T, Voss AK, Yip JW.
J Comp Neurol. 2012 Feb 20.

Reelin inhibits migration of sympathetic preganglionic neurons in the spinal cord of the chick.
Yip YP, Zhou G, Kubo K, Nakajima K, Yip JW.
J Comp Neurol. 2011 Jul 1;519(10):1970-8.

Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord.
Yip YP, Mehta N, Magdaleno S, Curran T, Yip JW.
J Comp Neurol. 2009 Jul 10;515(2):260-8.

Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord.
Yip YP, Capriotti C, Drill E, Tsai LH, and Yip JW.
J. Comp. Neur. 503: 297-307, 2007.

Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-regulated Dab1 tyrosine phosphorylation and CrkL.
Yip YP, Capriotti C, Kronstadt-O'Brien P, Cooper JA, and Yip JW.
J. Comp. Neur. 502: 635-643, 2007.

Components of the Reelin signaling pathway are expressed in the spinal cord.
Yip YP, Capriotti C, Magdaleno S, Benhayon D, Curran T, Nakajima K, and Yip JW.
J. Comp. Neur. 470:210-219, 2004.

Migratory pathway of sympathetic preganglionic neurons in normal and reeler mutant mice.
Yip YP, Capriotti C, and Yip JW.
J. Comp. Neur. 19: 94-105, 2003.

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